CoQ10 : Tous les Bienfaits pour le Cœur et la Santé Cardiovasculaire CoQ10: All the Benefits for Heart and Cardiovascular Health קו-קיו10: כל היתרונות לבריאות הלב והמערכת הקרדיווסקולרית
- Admin
- 15 janv.
- 6 min de lecture
translation below - traduction plus bas - תרגום למטה
scientific references below - références scientifiques plus bas - -הפניות מדעיות להלן
Français :
Titre : "CoQ10 : Tous les Bienfaits pour le Cœur et la Santé Cardiovasculaire"
Texte de présentation : "Le CoQ10, un puissant antioxydant, est de plus en plus reconnu pour ses bienfaits exceptionnels sur la santé cardiovasculaire. Utilisé à la fois en prévention et en traitement, il est souvent prescrit à des doses allant de 400 à 600 mg, offrant une efficacité remarquable. Les témoignages de médecins et de patients soulignent des améliorations significatives, parfois spectaculaires, dans la fonction cardiaque. Découvrez pourquoi le CoQ10 est devenu un allié essentiel pour votre cœur."
Anglais :
Title: "CoQ10: All the Benefits for Heart and Cardiovascular Health"
Introduction: "CoQ10, a powerful antioxidant, is increasingly recognized for its exceptional benefits on cardiovascular health. Used both preventively and therapeutically, it is often prescribed at doses ranging from 400 to 600 mg, providing remarkable efficacy. Testimonials from doctors and patients highlight significant, sometimes spectacular, improvements in heart function. Discover why CoQ10 has become an essential ally for your heart."
Hébreu :
כותרת: "קו-קיו10: כל היתרונות לבריאות הלב והמערכת הקרדיווסקולרית"
טקסט הצגה: "קו-קיו10, נוגד חמצון עוצמתי, זוכה להכרה הולכת וגוברת על יתרונותיו המיוחדים לבריאות הקרדיווסקולרית. הוא משמש הן למניעה והן לטיפול, ונרשם לעיתים קרובות במינונים של 400 עד 600 מ"ג, עם יעילות מרשימה. עדויות של רופאים ומטופלים מדגישות שיפורים משמעותיים ולעיתים מופלאים בתפקוד הלב. גלו מדוע קו-קיו10 הפך לבן ברית חיוני ללב שלכם."
resume article found: Coenzyme Q10 (CoQ10) has shown significant potential as a cardioprotective agent, particularly in improving mitochondrial function and enhancing systolic performance in cardiovascular disease (CVD) patients. A comprehensive meta-analysis found that CoQ10 supplementation significantly improved ejection fraction and mitochondrial respiratory capacity, indicating better heart function and energy production (Translational Cardiology, 2024). Historical studies have also demonstrated CoQ10's role in reducing the oxidative modification of LDL cholesterol, thus offering preventive benefits against atherosclerosis and coronary artery disease (Biofactors, 1999). Long-term clinical studies further confirm CoQ10's efficacy across a spectrum of cardiac conditions, from ischemic cardiomyopathy to hypertensive heart disease, with significant improvements in New York Heart Association (NYHA) functional class and reductions in cardiac medication requirements (Molecular Aspects of Medicine, 1994).
No. Source Key Insight Citations
1 Translational Cardiology (2024) CoQ10 improves ejection fraction and mitochondrial respiratory capacity in CVD patients. -
2 Biofactors (1999) Prevents LDL oxidation and supports mitochondrial function, aiding in cardiovascular health. 153
3 Molecular Aspects of Medicine (1994) Long-term use improves heart function and reduces reliance on other cardiac medications. 80
Zaleski AL, Taylor BA, Thompson PD. Adv Nutr. 2018 Jul 1;9(4):519S-523S. doi: 10.1093/advances/nmy010. PMID: 30032220 Free PMC article. Review.
Statins block the production of farnesyl pyrophosphate, an intermediate in the mevalonate pathway, which is responsible for the production of coenzyme Q10 (CoQ10). This knowledge has prompted the hypothesis that reductions in plasma CoQ10 concentration …
2
De Gennaro L, Brunetti ND, Correale M, Buquicchio F, Caldarola P, Di Biase M. Curr Atheroscler Rep. 2014 Jan;16(1):377. doi: 10.1007/s11883-013-0377-x. PMID: 24277654 Review.
Statins are effective in the prevention of coronary events and the treatment of acute coronary syndromes. ...On the basis of literature evidence from subgroup analysis, retrospective, prospective cohort studies, and randomized controlled trials, in this review we try to an …
3
High plasma coenzyme Q10 concentration is correlated with good left ventricular performance after primary angioplasty in patients with acute myocardial infarction.
Huang CH, Kuo CL, Huang CS, Tseng WM, Lian IB, Chang CC, Liu CS. Medicine (Baltimore). 2016 Aug;95(31):e4501. doi: 10.1097/MD.0000000000004501. PMID: 27495100 Free PMC article.
Exogenous administration of coenzyme Q10 (CoQ10) has been shown in experimental models to have a protective effect against ischemia-reperfusion injury. ...The control group comprised 54 healthy age- and sex-matched volunteers.Serial circulating CoQ1 …
4
Coenzyme Q10 to manage chronic heart failure with a reduced ejection fraction: a systematic review and economic evaluation.
Claxton L, Simmonds M, Beresford L, Cubbon R, Dayer M, Gottlieb SS, Hartshorne-Evans N, Kilroy B, Llewellyn A, Rothery C, Sharif S, Tierney JF, Witte KK, Wright K, Stewart LA. Health Technol Assess. 2022 Jan;26(4):1-128. doi: 10.3310/KVOU6959. PMID: 35076012 Free article.
OBJECTIVES: To assess the clinical effectiveness and cost-effectiveness of coenzyme Q10 in managing chronic heart failure with a reduced ejection fraction. ...However, given important concerns about risk of bias, plausibility of effect sizes and …
5
Hausse AO, Aggoun Y, Bonnet D, Sidi D, Munnich A, Rötig A, Rustin P. Heart. 2002 Apr;87(4):346-9. doi: 10.1136/heart.87.4.346. PMID: 11907009 Free PMC article. Clinical Trial.
No correlation was found between responsiveness to idebenone and age, sex, initial ultrasound indices, or the number of GAA repeats in the frataxin gene. CONCLUSIONS: Idebenone is effective at controlling cardiac hypertrophy in Friedreich's ataxia. As the drug has no serio …
Journal Article•DOI
1. Translational Cardiology: Practical Insights into the Coenzyme Q10 Role as Potential Therapeutic Agent for Cardiovascular Disease Treatment via Systematic Review and Meta-Analysis of Prospective Cohort Studies
30 Aug 2024-Translational medicine
CoQ10 supplementation has been shown to improve mitochondrial function and systolic performance in cardiovascular disease patients, with significant increases in ejection fraction, ATP production, and respiratory capacity, supporting its potential as an effective therapeutic agent for cardiovascular health.
Journal Article•DOI
2. The Role of Coenzyme Q10 in Cardiovascular Disease Treatment: An Updated 2024 Systematic Review and Meta-Analysis of Prospective Cohort Studies (2000-2023)
Julian Yin Vieira Borges
04 Jul 2024
CoQ10 supplementation significantly improves mitochondrial function and systolic performance in patients with cardiovascular diseases, evidenced by increased ATP production and enhanced ejection fraction. These findings suggest CoQ10 could be a valuable adjunctive therapy in cardiology.
Journal Article•DOI
3. Coenzyme Q10 mitigates cadmium cardiotoxicity by downregulating NF-kB/NLRP3 inflammasome axis and attenuating oxidative stress in mice.
Samar A. Antar, Walied Abdo, Azza I. Helal +10 more
01 May 2024-Life Science
Coenzyme Q10 (CoQ10) exhibits cardioprotective effects by mitigating cadmium-induced cardiotoxicity, reducing oxidative stress, and downregulating the NF-kB/NLRP3 inflammasome axis, thereby improving cardiac function and safeguarding cardiac tissue from damage.
Journal Article•DOI
4. Coenzyme Q10 mitigates macrophage mediated inflammation in heart following myocardial infarction via the NLRP3/IL1β pathway
Wenxu Pan
28 Jan 2024-BMC Cardiovascular Disorders
Coenzyme Q10 (CoQ10) significantly promotes early recovery of cardiac function after myocardial infarction by alleviating cardiac dysfunction, myocardial fibrosis, and hypertrophy, while inhibiting the recruitment of pro-inflammatory macrophages and suppressing the NLRP3/IL1β signaling pathway.
DOI
5. Comparison of Coenzyme Q10 (Ubiquinone) and Reduced Coenzyme Q10 (Ubiquinol) as Supplement to Prevent Cardiovascular Disease and Reduce Cardiovascular Mortality.
Johannes-Paul Fladerer, Selina Grollitsch
16 Nov 2023-Current Cardiology Reports
CoQ10 supplementation has been shown to reduce cardiovascular death in patients with heart failure, demonstrating significant cardiovascular benefits. In contrast, the reduced form, CoQH2, did not show similar outcomes, highlighting CoQ10's superior efficacy in cardiology.
DOI
6. Coenzyme Q10 in atherosclerosis.
Minjun Liao, Xueke He, Yangyang Zhou +1 more
01 Mar 2024-European Journal of Pharmacology
Coenzyme Q10 (CoQ10) has beneficial effects in cardiology by mitigating lipid transportation, reducing endothelial inflammation, addressing metabolic abnormalities, and influencing thrombotic processes, suggesting its potential use in treating atherosclerotic cardiovascular diseases, although further studies are needed.
Open access•Journal Article•DOI
7. Cardioprotective Effects of Coenzyme Q10 Supplementation on Patients with ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention
Amir Hossein Yazdi, Erfan Parvaneh, Seyed Kianoosh Hosseini +2 more
26 Mar 2023-Pharmaceutical sciences
CoQ10 supplementation may reduce myocardial ischemia-reperfusion injury and improve left ventricular function in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention, as evidenced by lower plasma levels of cardiac enzymes and better left ventricular ejection fraction.
Open access•Journal Article•DOI
8. Effect of coenzyme Q10 on cardiac function and survival in heart failure: an overview of systematic reviews and meta-analyses.
Irene Martínez-García, Irene Sequí-Domínguez, Eva Rodríguez-Gutiérrez +1 more
23 Jun 2023-Food & Function
CoQ10 supplementation may improve cardiac function, particularly ejection fraction, and reduce mortality and hospitalisations in heart failure patients. However, the evidence is limited, and further research is needed to determine optimal conditions and dosages for its effectiveness.
Open access•Journal Article•DOI
9. Coenzyme Q10 as Adjunctive Therapy for Cardiovascular Disease and Hypertension: A Systematic Review.
Carolyn B. Sue-Ling, Willie M. Abel, Keith Sue-Ling
28 Mar 2022-Journal of Nutrition
CoQ10 supplementation in cardiology has shown benefits, particularly in older adults with heart failure, improving functional capacity, increasing serum levels, and reducing major adverse cardiovascular events. It also positively affects inflammatory markers in ischemic heart disease patients.
Open access•Journal Article•DOI
10. Metabolic effects of coenzyme Q10, magnesium and vitamin D in cardiovascular diseases: a systematic review
Marcos Alberto Pires Meira Júnior
27 Jan 2023-International Journal of Nutrology
Coenzyme Q10 exerts protective antioxidant action, reduces lipid peroxides in atherosclerotic lesions, and is associated with low plasma concentrations in various cardiovascular conditions. It plays a crucial role in mitochondrial function, particularly in the heart, enhancing overall cardiovascular health.
